There’s a pool of blood in an alley, but no body. A white van was spotted fleeing the scene 20 minutes after a pair of gunshots rang out. An imprint matching a pricey briefcase is found in the blood. Lanie determines the victim is a male. Captain Gates is not impressed when Castle points out that this effectively eliminates about four million NYC ladies. Hey, it’s better than nothing, right? Wrong. Castle and Beckett need a body.

The team finds the mystery van. It was used to transport the body to a cryonics facility. A special watch worn by the victim, Lester Hamilton, alerted the company that one of their clients had died. The cryonics lab CEO, Dr. Ari Weiss (guest star William Atherton) says the victim developed techniques for life extension. Hamilton’s contract legally stops the cops from doing an autopsy. Once again, Castle and Beckett have no body.

Lester Hamilton’s wife, Cynthia, says her husband truly believed in life extension. She shared Lester’s sentiment that one lifetime together wouldn’t be enough for them. These two were truly in love. Lester’s colleague, Dr. Philip Boyd, explains that his friend was working on something called the Ambrosia Project. It involved pharmaceutical implants that would cause the body to produce young cells instead of aging ones.

Speaking of youth, Alexis learns she did not get into Stanford. She feels like a failure. Castle believes he may have overprotected his daughter to the point where she can’t handle rejection. He explains to Alexis why he keeps his first rejection letter in a frame. It’s what motivates him. Everyone gets rejected. How you handle it is what matters. Castle’s such good dad. As far as the case…